The incidence of injuries and deaths related to Exertional Heat Illness (EHI), Exertional Rhabdomyolysis (ER), and Cardiorespiratory Failure has increased significantly in college athletes in recent years. Data indicate that these injuries and deaths are more likely to occur during periods when athletes are transitioning from relative inactivity to regular training. To address this problem, the CSCCa and NSCA have created consensus guidelines which recommend upper limits on the volume, intensity, and work:rest ratio during transition periods where athletes are more vulnerable. The consensus guidelines provide strength and conditioning coaches with a clear framework for safe and effective program design in the first 2—4 weeks following periods of inactivity or return from EHI or ER. Adhering to the consensus guidelines, conducting preparticipation medical evaluations, and establishing emergency action plans will reduce the incidence of injuries and deaths in college athletes.