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The squat is one of the most widely used exercises in resistance training programs. The aim of this narrative review was to analyze the effect of the squat on lower-limb muscle hypertrophy. Briefly, the available literature indicates that the squat is an effective exercise for inducing hypertrophy of the quadriceps, mainly the vastii, but also the rectus femoris, although to a reduced magnitude. Multiple lines of evidence suggest little to no hamstring hypertrophy from the back squat. Although the gluteus maximus clearly participates mechanically in the back squat, few longitudinal studies exist on the topic. The limited evidence available on this topic suggests deeper squats may be more hypertrophic for the gluteus maximus, and that, squat depth beyond 908 of knee flexion may not provide further hypertrophy of the knee extensors. Despite the popularity of the many squat variations, there are still controversies surrounding their hypertrophic potential for lower-limb musculature. Further studies are needed to investigate the hypertrophic effects of different squat variations, as well as differences in hypertrophy because of squat depth, stance, barbell position, and different squat apparatuses/machines.

One resistance training variable that may be altered to achieve desired outcomes is the range of motion used in training. Generally, the strength and conditioning field has accepted that using a greater range of motion in strength training exercises results in more substantial muscle hypertrophy outcomes. However, this theory has proved to be inconsistently supported in the literature, and to date, no sufficient explanation exists to explain this phenomenon. This review article seeks to outline a novel approach for potentially describing the disparities seen in range of motion research with respect to hypertrophy outcomes by applying the unique length-tension curve of each muscle being examined. As will be discussed in the review, virtually all the results from range of motion studies in various muscles have corresponded to each muscle’s length-tension curve; muscles that are active on the descending limb of the curve appear to garner greater hypertrophy from using larger ranges of motion. Conversely, muscles that are not active on the descending limb exhibit similar adaptations despite alterations in range of motion. A novel hypothesis for applying this information to resistance training programs will be presented and discussed.

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