Lactate—A Multi-Faceted Metabolite

by Dr Carmine Grieco III, CSCS,*D
Personal Training Quarterly October 2019
Vol 6, Issue 2


This article discusses lactate testing as a cost-effective alternative way to create advanced exercise prescriptions, as well as opening the possibility of being a new biomarker of metabolic health for personal trainers.

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This article originally appeared in Personal Training Quarterly (PTQ)—a quarterly publication for NSCA Members designed specifically for the personal trainer. Discover easy-to-read, research-based articles that take your training knowledge further with Nutrition, Programming, and Personal Business Development columns in each quarterly, electronic issue. Read more articles from PTQ »

Related Reading



1. Brooks, GA, and Mercier, J. Balance of carbohydrate and lipid utilization during exercise: The “crossover” concept. Journal of Applied Physiology 76(6): 2253-2261, 1994.

2. Chondronikola, M, Magkos, F, Yoshino, J, Okunade, AL, Patterson, BW, Muehlbauer, MJ, et al. Effect of progressive weight loss on lactate metabolism: A randomized controlled trial. Obesity 26(4): 683-688, 2018.

3. Crawford, SO, Hoogeveen, RC, Brancati, FL, Astor, BC, Ballantyne, CM, Schmidt, MI, and Young, JH. Association of blood lactate with type 2 diabetes: The atherosclerosis risk in communities carotid MRI study. International Journal of Epidemiology 39(6): 1647-1655, 2010.

4. Goodpaster, BH, and Sparks, LM. Metabolic flexibility in health and disease. Cell Metabolism 25(5): 1027-1036, 2017.

5. Goodwin, ML, Harris, JE, Hernández, A, and Gladden, LB. Blood lactate measurements and analysis during exercise: A guide for clinicians. Journal of Diabetes Science and Technology 1(4): 558-569, 2007.

6. Haff, GG, and Triplett, NT. Essentials of Strength Training and Conditioning. Champaign, IL: Human Kinetics; 2016.

7. Lee, DC, Sui, X, Church, TS, Lee, IM, and Blair, SN. Associations of cardiorespiratory fitness and obesity with risks of impaired fasting glucose and type 2 diabetes in men. Diabetes Care 32(2): 257-262, 2009.

8. Miranda, H, Maia, MF, Paz, GA, de Souza, JAAA, Simão, R, Farias, DA, and Willardson, JM. Repetition performance and blood lactate responses adopting different recovery periods between training sessions in men. Journal of Strength and Conditioning Research 32(12): 3340-3347, 2018.

9. Robergs, RA, Ghiasvand, F, and Parker, D. Biochemistry of exercise-induced metabolic acidosis. American Journal of Physiology 287(3): R502-516, 2004.

10. Robergs, RA, McNulty, CR, Minett, GM, Holland, J, and Trajano, G. Lactate, not lactic acid, is produced by cellular cytosolic energy catabolism. Physiology 33: 10-12, 2018.

11. Todd, JJ. Lactate: Valuable for physical performance and maintenance of brain function during exercise. Bioscience Horizons 7: 2014.

12. Toledo, FG, Menshikova, EV, Ritov, VB, Azuma, K, Radikova, Z, DeLany, J, and Kelley, DE. Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes 56(8): 2142-2147, 2007.

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Carmine R. Grieco III, PhD, CSCS,*D

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Carmine Grieco received his Doctoral degree from Old Dominion University at the age of 43 and is now an Assistant Professor of Kinesiology at Colorado ...

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