Firefighting is a profession that has the potential to be extremely demanding, both physically and mentally. More specifically, these tactical personnel must be physically fit to perform their occupational requirements, all while they are exposed to daily stressors. This is likely to include everything from physical strain and shift work to interrupted sleep and witnessing potentially traumatizing events. Failure to prepare and mitigate these occupational demands can have long-lasting implications to overall performance as well as health and wellness. Unfortunately, many of these elements often go unaddressed. As such, considerations for collaborative and overarching cross-disciplinary allied health teams should be made. Human performance optimization (HPO) is a model that has been successfully adopted by the U.S. military to enhance the overarching health, wellness, and performance of soldiers. This article proposes the utilization of a similar HPO model by providing a rationale for how it can be used to reduce premature morbidity and mortality, as well as increasing overall readiness and resilience within the firefighting profession.